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BOOK SUMMARY :

Neuregulins are egf like growth and differentiation factors that interact with tyrosine kinase receptors of the erbb family this signailing system has a wide range of functions during development of the nervous system the heart and the mammary glandneuregulins nrgs comprise a large family of egf like signaling molecules involved in cell cell communication during development and disease the neuregulin family of ligands has four members nrg1 nrg2 nrg3 and nrg4 relatively little is known about the biological functions of the nrg2 3 and neuregulin 1 nrg 1 a cardioactive growth factor released from endothelial cells is indispensable for cardiac development structural maintenance and functional integrity of the heartthe neuregulin ierbb signaling system in development and disease advances in anatomy embryology and cell biology 2007 190165 11 steinthorsdottir v stefansson h ghosh s birgisdottir b bjornsdottir s fasquel ac olafsson o stefansson k gulcher jr multiple novel transcription initiation sites for nrg12007 biology of the neuregulinerbb signaling network in the neuregulin ierbb signaling system in development and disease advances in anatomy embryology and cell biology vol 190

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